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N-acetyl cysteine and L-carnitine effect on CCl4-hepatotoxicity: Hepatoprotective effect of N-acetyl cysteine and L-carnitine on CCl4-treated rats

  • Mã sản phẩm: 3659114995
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  • Publisher:LAP LAMBERT Academic Publishing (May 11, 2012)
  • Language:English
  • Paperback:216 pages
  • ISBN-10:3659114995
  • ISBN-13:978-3659114991
  • Item Weight:11.5 ounces
  • Dimensions:5.91 x 0.49 x 8.66 inches
3,142,000 vnđ
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N-acetyl cysteine and L-carnitine effect on CCl4-hepatotoxicity: Hepatoprotective effect of N-acetyl cysteine and L-carnitine on CCl4-treated rats
N-acetyl cysteine and L-carnitine effect on CCl4-hepatotoxicity: Hepatoprotective effect of N-acetyl cysteine and L-carnitine on CCl4-treated rats
3,142,000 vnđ
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Present work aimed to evaluate the protective effect of L-carnitine and/or N-acetyl cysteine (NAC) on CCl4-hepatotoxicity. Male albino rats were classified into 8 groups. Group I: normal control group. Group II: treated with L-carnitine. Group III: treated with NAC. Group IV: treated with L-carnitine and NAC. Group V: received CCl4 and served as cirrhotic control group. Group VI: treated with L-carnitine and CCl4. Group VII: received CCl4 and treated with NAC. Group VIII: treated with L-carnitine, NAC and received CCl4. Samples are collected and parts of the livers are preserved for histology. Results showed that treatment with CCl4 induced a significant increase in serum alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities, plasma sialic acid, total bilirubin, nitrite levels, and liver lipid peroxide content. Also, it induced a significant reduction in plasma albumin level, liver total protein, glutathione, and vitamin C contents. In the present study, it could be noticed (from the treatment with L-carnitine and NAC) that there were pronounced improvements in all studied parameters. We recommend a collective combination of L-carnitine and NAC.

 

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