PEA is found in nearly all animal tissues, human breast milk, and many foods. Our body produces PEA to protect and repair tissues and minimize pain. Since its discovery in 1957, PEA has been studied extensively for its anti-inflammatory, neuro-protective and analgesic properties.*
PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses.
Luteolin is a bioflavonoid with potent antioxidant and anti-inflammatory properties. It is naturally occurring in many foods including; artichoke, celery, parsley and peanuts.
Like PEA, luteolin has several mechanisms of action. It inhibits mast cells, as well as mast cell-dependent T cell activation. Luteolin modulates microglial activation and inhibits pro-inflammatory cytokine production. It also acts on GABA and opioid receptors in the spinal cord.*
The combination of PEA with luteolin has been shown to decrease mast cell activation significantly more than PEA or luteolin alone, and to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.*
Reduce Pain and Inflammation Naturally with the Combined Action of Palmitoylethanolamide (PEA) and Luteolin.* Provides natural support for the entire body including the nervous, immune and digestive systems.*
In a recent meta-analysis of PEA involving a total of 1484 chronic pain patients, those taking PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days.* (Paladini 2016) PEA regulates many physiological responses associated with pain and inflammation.*
Every ingredient is first tested by a third-party lab in the USA. Then, after mixing and encapsulation, Mirica is tested once more for purity and potency.
Mirica 60 Capsules | Mirica Advanced | Mirica Immune | Mirica Mood Lift | Luteolin Complex | |
---|---|---|---|---|---|
Benefits | Calm and Protect the Nervous System* Support a Healthy Immune Response* Down-modulates Mast Cells* Modulates Glial Cells* | Enhanced Absorption Formula with nearly 2X bioavailability | Support a Healthy Immune Response* Down-modulates Mast Cells* Modulates Glial Cells* | Promotes a Positive Mood* Helps the Body Adapt to Stresses of Daily Life* Supports Overall Brain Health* | Helps Maintain Nervous System Health* Supports a Healthy Immune Response* Powerful Free-radical Scavenger* |
Purchased By People Looking For… | Pain reduction* Immune System support* Nervous system support* | Same benefits as Mirica Original Formula with half as many capsules Faster pain reduction* | Powerful immune system support* and pain reduction* | A positive mood* Increased energy* Improved Mental Focus* | Antioxidants* Improving the benefits of Mirica supplements* |
Highlights | Features PEA & Luteolin combo, clinically studied for synergistic benefits Safe and side-effect free, even at highest dosage Mild flavored contents -Capsules can be easily opened and mixed into food or beverage | Features Levagen+ PEA with LipiSperse technology for nearly twice the absorption rate of standard PEA**, along with luteolin for increased benefit* Mild flavored contents -Capsules can be easily opened and mixed into food or beverage | Features Levagen+ PEA with LipiSperse technology for nearly twice the absorption rate of standard PEA**, along with luteolin for increased benefit*. Vitamin C is naturally derived from tomatoes, sourced from Israel | Features Levagen+ PEA with LipiSperse technology for nearly twice the absorption rate of standard PEA**, along with luteolin for increased benefit* Tyrosine is essential in the production of mood-boosting neurotransmitters* | With Vitamin C and Rutin for improved bioavailability* Vitamin C is naturally derived from tomatoes, sourced from Israel Luteolin is sourced from sophora flower |
Ingredients | Levagen Palmitoylethanolamide, Sunflower Lecithin, Luteolin, Veggie Capsule. | Levagen+ Palmitoylethanolamide, Luteolin, Rice Flour, Veggie Capsule. | Vitamin C, Vitamin D, Zinc Picolinate, Levagen+ Palmitoylethanolamide, Resveratrol, Polydatin, Rutin, Luteolin, Rice Flour, Veggie Capsule. | Tyrosine, Rhodiola Rosea, Levagen+ Palmitoylethanolamide, Luteolin, Veggie Capsule. | Vitamin C, Luteolin, Rutin, Rice Flour, Veggie Capsule. |
Dosage | Starting Dose: Take 2 capsules in the morning and 2 capsules in the evening for four weeks. Dosage can be increased to up to six capsules per day for greater benefit. Maintenance Dose: Take 1 capsule twice daily. | Take 1 capsule in the morning and 1 capsule in the evening. Dosage may be increased to 2 capsules twice per day for increased benefit. | Take 1 capsule in the morning and 1 capsule in the evening. | Take 1 capsule in the morning at least 30 minutes before eating. One additional capsule may be taken as needed. | Take 1 capsule daily. |
References:
1. Steels, Elizabeth et al. “A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of...” Inflammopharmacology vol. 27,3 (2019): 475-485. doi:10.1007/s10787-019-00582-9
2. Mallard, Alistair et al. “The Effect of Orally Dosed Levagen+ (palmitoylethanolamide) on Exercise Recovery in Healthy Males-A Double-Blind, Randomized, Placebo-Controlled Study.” Nutrients vol. 12,3 596. 25 Feb. 2020, doi:10.3390/nu12030596
* The statements on this website have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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